The AAD group and Dr. Urish are enormously appreciative of the Orthopaedic Research and Education Foundation for their generous support in improving orthopaedic research. We are excited to have been given the Galante Total Joint Replacment Award. This three year grant will support our laboratory to improve and extend implant survival by investigating new methods to treat infection.Read More
Peptilogics Received Qualified Infectious Disease Product Designation from the FDA for Lead Compound PLG0206 as a Treatment for Prosthetic Joint Infection.
We are very proud of our involvment with Peptilogics to help introduce a new antimicrobial compound, PLG0206, to prevent and fight surgical infection. More information can be found here.Read More
Dr. Urish's group report on a new class of antimicrobial agents to fight and prevent surgical infection. The new pre-clinical compound, WLBU2, has an increased ability to fight infection on surgical implants and against antimicrobial resistant bacteria.
The manuscript was published in Nature Scientific Reports.
You can see the pubmed posting here.
Download the original article here.
The Bone and Joint Center and AAD Group has started a prospective study looking at improved functional biomechanics with robotic surgery.Read More
Dr. Urish talked with Needham & Co. about robotics in total knee replacement surgery. The discussion was picked up by SmartTRAK.
The three main points were that robotic surgery is the next logical step in computer navigation - to execute a perfectly planned total knee arthroplasty. A fundamental problem in knee arthroplasty is the inability to consistently restore normal knee kinematics. Developing a solution to this problem would be the next big step in the field. Robotic assisted knee surgery has the potential to help solve this problem. His preference is the Smith & Nephew system, but both major players have excellent systems on the market that deliver similar results.
The headline for the article in SmartTrak missed the emphasis of the talk. Currently, robotic total knee arthroplasty has a valuable role, but it is not the standard of care. Developing the right implant design to preserve normal knee kinematics and consistently give patients "knee amnesia" will likely require robotic technology. This technology would have enormous potential.
You can read a summary of the entire Needham discussion here.
The original SmartTRAK post is here.
Dr. Mandell has been awarded a Pittsburgh Foundation award for his investigations in reducing surgical site infection. Congrats! #ChallangeAcceptedRead More
A special thanks to everyone at the Westinghouse SURE outreach meeting. The group had exceptional questions on hip and knee arthritis. This is a great example of what makes Pittsburgh great.Read More
Dr. Urish is featured in Orthopedics talking about robotic surgical knee replacement.Read More
Learn about options and the latest advancements in hip and knee arthritis from the area experts.Read More
Wanyan is the newest addition to the lab group. A talented freshman at Pitt, she will be working on developing new PCR assays for surgical infection diagnosis.Read More
Jon Mandall received a Ferguson Grant from the Pittsburgh Foundation with his work using new antibacterial compounds to eradicate infection on orthopaedic implants.Read More
The ADD lab was invited to the Musculoskeletal Infection Society’s Specialty Day at the AAOS 2017 Annual Meeting in San Diego. Saturday March 18, 2017.Read More
The AAD lab is a recipient of support from the OREF for new work looking at new ways to combat surgical infections.Read More
Dr. Ma's publication explains how antibiotics are inadequate at complete removal of the biofilm from the surface of Total Knee Arthroplasty (TKA) materials. Results suggest that bacterial persisters are responsible for this phenotypic behavior allowing biofilm high tolerance to antibiotics.Read More
Dr Urish talks about the importance of OREF in orthopaedic innovation.Read More